Diana Guardato was a member of the aristocratic Patrician Guardato family. She had at least two children with King Ferdinand I.

Her first child was Fernando de Aragón, 1st Duke of Montalto^[1] who married 1st, Anna Sanseverino, 2nd, Castellana de Cardona whose daughter Maria d'Aragona, married Antonio Todeschini Piccolomini, Duke of Amalfi, a nephew of Pope Pius II and brother of Pope Pius III.

Her second child was Giovanna d’ Aragona, who married Leonardo della Rovere, Duke of Arce and Sora, a nephew of Pope Sixtus IV and brother of Pope Julius II.