The Descendants of John VI of Portugal, of the House of Braganza, would play a significant role in Portuguese imperial affairs and numerous royalty affairs globally. Many descendants of John VI of Portugal and Carlota Joaquina of Spain became key figures in numerous historic events that followed.

His descendants can still be traced in both reigning and non-reigning royal families of Europe and Brazil. In fact, mainly through his second son, Miguel, nicknamed the "Grandfather of Europe", some of his descendants were recent rulers in Belgium, Luxembourg, Liechtenstein and were claimants to the thrones of Portugal, Austria and the former Duchy of Parma.^{[citation needed]}

John, born on 13 May 1767 in Lisbon, was the second son of Queen Maria I and King Pedro III.

John VI became the heir to the Portuguese throne after his brother, José, Prince of Brazil, died in 1788.

In 1799, John VI became Prince regent for his mother, Maria I of Portugal. Spain and France soon declared war and attempted to invade Portugal, starting the War of the Oranges. While peace was eventually attained, the Portuguese Empire suffered territorial losses.^[1]

In 1807, to safeguard the House of Braganza and its rule over the Portuguese Empire against Napoleon's influence and aggression, John moved the Portuguese court and capital to a safer location in the empire, Colonial Brazil. To satisfy the etiquette required by European society, John VI raised Brazil to a kingdom, forming the United Kingdom of Portugal, Brazil, and the Algarves.

In Rio de Janeiro, John VI established his court. In 1816, Maria I died and John was acclaimed King John VI of Portugal, Brazil, and the Algarves. By this time, Napoleon had been defeated and European courts demanded the return of the Portuguese court to Europe, which John eventually did, leaving Pedro, Prince Royal as regent of Brazil. Refusing to return to Europe, Pedro declared Brazil independent.

When John died, a crisis of succession occurred over the Portuguese throne. John's eldest sons and granddaughter split the House of Braganza into three branches, the original House of Braganza, the Brazilian House of Braganza, and the Miguelist House of Braganza.

On 8 May 1785, John married Carlota Joaquina of Spain. The couple had 9 children.

Descendant	Image	Birth	Marriages	Death
Maria Teresa of Braganza, Princess of Beira 1793–1874		29 April 1793 Palace of Ajuda daughter of John VI and Carlota Joaquina of Spain	Infante Pedro Carlos of Spain and Portugal 13 May 1810 1 child Carlos V of Spain (carlist) June 1838 no children	17 January 1874 Trieste aged 80
Infante Sebastian of Portugal and Spain 1811–1875		4 November 1811 Rio de Janeiro son of Maria Teresa, Princess of Beira and Infante Pedro Carlos of Spain and Portugal	Maria Amalia of Bourbon-Two Sicilies 25 May 1832 no children Maria Cristina of Spain 19 November 1860 5 children	13 January 1875 Pau aged 63
Francisco María, Duke of Marchena 1861–1923		20 August 1861 Madrid son of Infante Sebastian of Portugal and Spain and Maria Cristina of Spain	María del Pilar of Muguiro and Beruete 7 January 1886 3 children	17 November 1923 Neuilly-sur-Seine aged 62
María Cristina, Duchess of Marchena 1889–1981		27 July 1889 Paris daughter of Francisco María, Duke of Marchena and María del Pilar of Muguiro and Beruete	Leopold Walford November 11, 1911 2 children	3 October 1981 London aged 92
Juan Jorge, Duke of Ansola and Marchena 1912–1999		20 August 1912 Paris son of María Cristina, Duchess of Marchena and Leopold Walford	Emanuela Hawkins 1935 7 children	22 February 1999 London aged 87
Juan Jacobo, Duke of Marchena 1941–present		27 July 1941 London son of Juan Jorge, Duke of Ansola and Marchena and Emanuela Hawkins	not married

Descendant	Image	Birth	Marriages	Death
Francisco António of Braganza, Prince of Beira 1795–1801		21 March 1795 Queluz Palace son of John VI and Carlota Joaquina of Spain	never married	11 June 1801 Queluz Palace aged 6

Descendant	Image	Birth	Marriages	Death
Maria Isabel of Braganza 1797–1818		19 May 1797 Queluz Palace daughter of John VI and Carlota Joaquina of Spain	Ferdinand VII of Spain 29 September 1816 1 child	26 December 1818 Royal Palace of Madrid aged 21

Descendant	Portrait	Birth	Marriages	Death
Pedro IV of Portugal 1826–1826		12 October 1798 Queluz, Sintra son of John VI of Portugal and Charlotte of Spain	Maria Leopoldina of Austria 1817 7 children Amélie of Leuchtenberg 1829 1 child	24 September 1834 Queluz, Sintra aged 35
Maria II of Portugal 1826–1853		4 April 1819 Rio de Janeiro daughter of Pedro I and IV of Brazil and Portugal and Maria Leopoldina of Austria	Auguste de Beauharnais, 2nd Duke of Leuchtenberg 1834 no children Fernando of Saxe-Coburg-Gotha 1837 11 children	15 November 1853 Lisbon aged 34
Pedro V of Portugal 1853–1861		16 September 1837 Lisbon son of Maria II of Portugal and Fernando II of Portugal	Stephanie of Hohenzollern-Sigmaringen 1858 no children	11 November 1861 Lisbon aged 24
Luís I of Portugal 1861–1889		31 October 1838 Lisbon son of Maria II of Portugal and Fernando II of Portugal brother of Pedro V of Portugal	Maria Pia of Savoy 1863 2 children	19 October 1889 Lisbon aged 50
Carlos I of Portugal 1889–1908		28 September 1863 Lisbon son of Luís I of Portugal and Maria Pia of Savoy	Amélie of Orléans 1886 3 children	1 February 1908 Lisbon aged 44
Luís Filipe, Prince Royal of Portugal 1908–1908		21 March 1887 Lisbon son of Carlos I of Portugal and Amélie of Orléans	never married	1 February 1908 Lisbon aged 20
Manuel II of Portugal 1908–1910		19 March 1889 Lisbon son of Carlos I of Portugal and Amélie of Orléans brother of Luís Filipe, Prince Royal of Portugal	Augusta Victoria of Hohenzollern-Sigmaringen 1913 no children	2 July 1932 Fulwell, London aged 42

Descendant	Portrait	Birth	Marriages	Death
Pedro I of Brazil 1821–1831		12 October 1798 Queluz, Sintra son of John VI of Portugal and Charlotte of Spain	Maria Leopoldina of Austria 1817 7 children Amélie of Leuchtenberg 1829 1 child	24 September 1834 Queluz, Sintra aged 35
Pedro II of Brazil 1831–1891		2 December 1825 Rio de Janeiro son of Pedro I of Brazil and Maria Leopoldina of Austria	Teresa of the Two Sicilies 17 September 1842 4 children	5 December 1891 Paris aged 66
Isabel, Princess Imperial of Brazil 1891–1921		29 July 1846 Rio de Janeiro daughter of Pedro II of Brazil and Teresa of the Two Sicilies	Gaston, Count of Eu 15 October 1864 3 children	14 November 1921 Eu, Seine-Maritime aged 75
Pedro Henrique of Orléans-Braganza 1921–1981		13 September 1909 Boulogne-Billancourt son of Prince Luís of Orléans-Braganza and Princess Maria di Grazia of Bourbon-Two Sicilies	Princess Maria Elisabeth of Bavaria 19 August 1937 12 children	5 July 1981 Vassouras aged 71
Prince Luiz of Orléans-Braganza 1981–2022		6 June 1938 Mandelieu-la-Napoule son of Pedro Henrique of Orléans-Braganza and Princess Maria Elisabeth of Bavaria	never married	15 July 2022 São Paulo aged 84
Prince Bertrand of Orléans-Braganza 2022–present		2 February 1941 Mandelieu-la-Napoule son of Pedro Henrique of Orléans-Braganza and Princess Maria Elisabeth of Bavaria	not married

Descendant	Image	Birth	Marriages	Death
Maria Francisca of Braganza 1800–1834		22 April 1800 Queluz Palace daughter of John VI and Carlota Joaquina of Spain	Infante Carlos, Count of Molina 22 September 1816 3 children	4 September 1834 Alverstoke aged 34
Infante Carlos, Count of Montemolin 1818–1861		31 January 1818 Madrid son of Maria Francisca of Portugal and Infante Carlos, Count of Molina	Maria Carolina of Bourbon-Two Sicilies 10 July 1850 no children	13 January 1861 Trieste aged 43
Juan, Count of Montizón 1822–1887		15 May 1822 Royal Palace of Aranjuez son of Maria Francisca of Portugal and Infante Carlos, Count of Molina	Maria Beatrix of Austria-Este 6 February 1847 2 children	18 November 1887 Hove aged 65
Carlos, Duke of Madrid 1848–1909		30 March 1848 Ljubljana son of Juan, Count of Montizón and Maria Beatrix of Austria-Este	Margherita of Bourbon-Parma 4 February 1867 5 children Berthe de Rohan 28 April 1894 no children	18 July 1909 Varese aged 61
Jaime, Duke of Madrid 1870–1931		27 June 1870 Vevey son of Carlos, Duke of Madrid and Margherita of Bourbon-Parma	never married	2 October 1931 Paris aged 61
Infanta Blanca of Spain 1868–1949		7 September 1868 Graz daughter of Carlos, Duke of Madrid and Margherita of Bourbon-Parma	Leopold Salvator, Prince of Tuscany 24 October 1889 10 children	25 October 1949 Viareggio aged 81
Anton, Prince of Tuscany 1901–1987		20 March 1901 Vienna son of Blanca of Spain and Leopold Salvator, Prince of Tuscany	Ileana of Romania 26 July 1931 6 children	22 October 1987 Salzburg aged 86
Archduke Stefan of Austria 1932–1998		15 August 1932 Mödling son of Anton, Prince of Tuscany and Ileana of Romania	Mary Jerrine Soper 26 August 1954 5 children	12 November 1998 Brighton aged 66
Christopher Habsburg-Lothringen 1957–present		26 January 1957 Boston son of Archduke Stefan of Austria and Mary Jerrine Soper	Elizabeth Ann Blanchette 2 May 1987 2 children
Saygan Genevieve Habsburg-Lothringen 1987–present		31 October 1987 Mill Valley son of Christopher Habsburg-Lothringen and Elizabeth Ann Blanchette	not married

Descendant	Image	Birth	Marriages	Death
Isabel Maria of Braganza 1801–1876		4 July 1801 Queluz Palace daughter of John VI and Carlota Joaquina of Spain	never married	22 April 1876 Belém aged 74

Descendant	Image	Birth	Marriages	Death
Miguel I of Portugal 1802–1866		26 October 1802 Queluz Palace son of John VI and Carlota Joaquina of Spain	Adelaide of Löwenstein-Wertheim-Rosenberg 24 September 1851 7 children	14 November 1866 Esselbach aged 64
Miguel, Duke of Braganza 1853–1927		19 September 1853 Kleinheubach son of Miguel I and Adelaide of Löwenstein-Wertheim-Rosenberg	Elisabeth of Thurn and Taxis 17 October 1877 3 children Maria Theresa of Löwenstein-Wertheim-Rosenberg 8 November 1893 8 children	11 October 1927 Seebenstein aged 74
Miguel, Duke of Viseu 1878–1923		22 September 1878 Reichenau an der Rax son of Miguel, Duke of Braganza and Elisabeth of Thurn and Taxis	Anita Stewart Morris 15 September 1909 3 children (declared morganatic)	21 February 1923 New York City aged 44
Duarte Nuno, Duke of Braganza 1907–1976		23 September 1907 Seebenstein son of Miguel, Duke of Braganza and Maria Theresa of Löwenstein-Wertheim-Rosenberg	Francisca of Orléans-Braganza 15 October 1942 3 children	24 December 1976 Seebenstein aged 69
Duarte Pio, Duke of Braganza 1945–present		15 May 1945 Bern son of Duarte Nuno, Duke of Braganza and Francisca of Orléans-Braganza	Isabel Inês de Castro Curvelo de Herédia 13 May 1995 3 children
Afonso, Prince of Beira 1996–present		25 March 1996 Lisbon son of Duarte Pio, Duke of Braganza and Isabel Inês de Castro Curvelo de Herédia	not married

Descendant	Image	Birth	Marriages	Death
Maria da Assunção of Braganza 1805–1834		25 June 1805 Queluz Palace daughter of John VI and Carlota Joaquina of Spain	never married	7 January 1834 Santarém aged 29

Descendant	Image	Birth	Marriages	Death
Ana de Jesus Maria of Braganza 1806–1834		23 October 1806 Mafra Palace daughter of John VI and Carlota Joaquina of Spain	Nuno de Mendoça Rolim de Moura Barreto, Duke of Loulé 5 December 1827 5 children	22 June 1857 Rome aged 50
Pedro de Mendoça Rolim de Moura Barreto, Duke of Loulé 1830–1909		7 October 1830 Paris son of Ana de Jesus Maria of Portugal and Nuno de Mendoça Rolim de Moura Barreto, Duke of Loulé	Constança Maria de Figueiredo Cabral da Camara 19 April 1852 2 children	2 March 1909 Belém aged 79
Maria de Mendoça Rolim de Moura Barreto, Duchess of Loulé 1853–1928		3 March 1853 Belém daughter of Pedro de Mendoça Rolim de Moura Barreto, Duke of Loulé and Constança Maria de Figueiredo Cabral da Camara	João Maria dos Enfermos da Camara Berquó 18 June 1887 1 child	12 September 1928 Belém aged 75
Constança de Mendoça Rolim de Moura Barreto, Duchess of Loulé 1889–1967		18 August 1889 Belém daughter of Maria de Mendoça Rolim de Moura Barreto, Duchess of Loulé and João Maria dos Enfermos da Camara Berquó	José Pedro de Basto Feio Folque 22 May 1921 5 children	14 December 1967 Belém aged 79
Alberto de Mendoça Rolim de Moura Barreto, Duke of Loulé 1923–2003		10 July 1923 Belém son of Constança de Mendoça Rolim de Moura Barreto, Duchess of Loulé and José Pedro de Basto Feio Folque	Maria Augusta Amélia de Morais Cardoso de Menezes 8 July 1953 8 children	24 September 2003 Cascais aged 80
Pedro de Mendoça Rolim de Moura Barreto, Duke of Loulé 1958–present		9 March 1958 Lisbon son of Alberto de Mendoça Rolim de Moura Barreto, Duke of Loulé and Maria Augusta Amélia de Morais Cardoso de Menezes	Margarida Corrêa de Barros Vaz Pinto 1997 2 children
D. Henrique Nuno de Mendoça Rolim de Moura Barreto 1997–present		21 August 1997 Lisbon son of Pedro de Mendoça Rolim de Moura Barreto, Duke of Loulé and Margarida Corrêa de Barros Vaz Pinto	not married

• Descendants of Manuel I of Portugal
• Descendants of Miguel I of Portugal