Chrome Dome may refer to:

• Chrome dome, a case of hair loss to where a person goes bald
• Chrome Dome, a fictional character a.k.a. Mr. Cooper in Sweet Valley High novels
• Chrome Dome, a fictional character debuting in season 5 of Teenage Mutant Ninja Turtles
• Chrome Dome Empire, a fictional organization in Cyber City setting for comics
• Chromedome (Transformers), a fictional character in the Transformers universe
• A nickname for either Cobra Commander or Destro in the G.I. Joe universe
• A nickname for Mr RH Allen legendary librarian of Dartford Boys Grammar School (now deceased)
  • Professor Chromedome, in The Tick comics

• Operation Chrome Dome, a U.S. Cold-War strategic-bomber program