Cesarini is an Italian surname and the name of an Italian noble family. Notable people mostly include members of the noble Cesarini family, who held various ecclesiastical titles.

• Alessandro Cesarini (died 1542), Italian cardinal
• Alessandro Cesarini (footballer) (born 1989), Italian footballer
• Alessandro Cesarini (iuniore) (1592–1644), Italian Roman Catholic bishop
• Carlo Francesco Cesarini (c. 1666–1741), Italian classical composer and violinist
• Claudia Cesarini (born 1986), Italian modern pentathlete
• David Cesarini, American economist
• Davide Cesarini (born 1995), Sammarinese footballer
• Ferdinando Cesarini (1604–1646), Italian poet and physicist
• Filippo Cesarini (1610–1683), Italian Roman Catholic bishop
• Giuliano Cesarini, iuniore (1466–1510), Italian cardinal
• Julian Cesarini (1398–1444), Italian cardinal
• Nino Cesarini (1889–1943), Italian model
• Renato Cesarini (1906–1969), Italian Argentine footballer and manager
• Virginio Cesarini (1595–1624), Italian poet and intellectual
• Giovanni Andrea Cesarini. He married Girolama Borgia, an Illegittime daughter of Pope Alexander VI

• Cesarini v. United States, a United States district court case
• Ceserani