Gomez and Blanco began teasing their collaboration with Abrams on February 17, when Blanco shared a video on his social media where he enters a bedroom and finds Gomez and Abrams chatting on the bed, he asks them: "What are you guys doing in here?" and they both reply: "Hello!".[3] The next day, Gomez posted a selfie-style clip lip syncing along to an unreleased track. "Call me when you break up/ I want to be the first one on your mind when you wake up/ I miss the way we'd stay up/ We'd talk about forever while I’m taking off my makeup".[3] On the same day, Gomez introduced the song to her fans during a special event to promote her album, I Said I Love You First, in London, United Kingdom, while Abrams performed her verse of the song during her concert on her The Secret of Us Tour in Hamburg, Germany.[4]
On February 20, 2025, "Call Me When You Break Up" was released for download and streaming, along with the video shot on the front-facing camera, it shows Gomez and Abrams singing along to their new song while in a bedroom.[2] The next day, it was sent to Italian radio stations by Universal Music Group,[5] as well as on American contemporary hit radio,[6] and on United Kingdom radio on February 28, 2025.[7]
