CDH15

CDH15
Identifiers
Aliases	CDH15, CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDs	OMIM: 114019; MGI: 106672; HomoloGene: 3622; GeneCards: CDH15; OMA:CDH15 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	89,195,492 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,594,136 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	1013
	12555
	ENSG00000129910
	ENSMUSG00000031962
	P55291
	P33146
	NM_004933
	NM_007662
	NP_004924
	NP_031688
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.^[5]^[6]

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[6]

Interactions

CDH15 has been shown to interact with ARVCF.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129910 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031962 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
^ ^a ^b "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".
^ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A (1991). "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8024–8. Bibcode:1991PNAS...88.8024D. doi:10.1073/pnas.88.18.8024. PMC 52438. PMID 1840697.
Bornemann A, Schmalbruch H (1994). "Immunocytochemistry of M-cadherin in mature and regenerating rat muscle". Anat. Rec. 239 (2): 119–25. doi:10.1002/ar.1092390202. PMID 8059975. S2CID 43526913.
Shibata T, Shimoyama Y, Gotoh M, Hirohashi S (1997). "Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning". J. Biol. Chem. 272 (8): 5236–40. doi:10.1074/jbc.272.8.5236. PMID 9030594.
Kuch C, Winnekendonk D, Butz S, Unvericht U, Kemler R, Starzinski-Powitz A (1997). "M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells". Exp. Cell Res. 232 (2): 331–8. doi:10.1006/excr.1997.3519. PMID 9168809.
Shimoyama Y, Shibata T, Kitajima M, Hirohashi S (1998). "Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin". J. Biol. Chem. 273 (16): 10011–8. doi:10.1074/jbc.273.16.10011. PMID 9545347.
Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (2001). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.
Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMC 14619. PMID 11136230.
Hollnagel A, Grund C, Franke WW, Arnold HH (2002). "The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration". Mol. Cell. Biol. 22 (13): 4760–70. doi:10.1128/MCB.22.13.4760-4770.2002. PMC 133893. PMID 12052883.
Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. Bibcode:2003PNAS..100.3989K. doi:10.1073/pnas.0736565100. PMC 153035. PMID 12634428.

External links

CDH15 human gene location in the UCSC Genome Browser.
CDH15 human gene details in the UCSC Genome Browser.
Human CDH3 genome location and CDH3 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129910 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031962 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427864-5] Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.

[entrez-6] "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".

[pmid11058098-7] Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell Sci. 113 (22): 4121–35. doi:10.1242/jcs.113.22.4121. PMID 11058098.

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