C5, C05, C V or C-5 may refer to:

• Lockheed C-5 Galaxy, a military transport aircraft
• C-5 North Star, a 1940s Canadian military aircraft
• HMS C5, a 1906 Royal Navy C-class submarine
• USS C-5 (SS-16), a 1908 United States Navy C-class submarine
• USS San Francisco (C-5), an 1889 United States Navy protected cruiser
• Albatros C.V, a World War I German military reconnaissance aircraft
• AEG C.V, a World War I prototype German two-seat biplane reconnaissance aircraft
• DFW C.V, a World War I German military reconnaissance aircraft
• Fokker C.V, a 1924 Dutch light reconnaissance and bomber biplane aircraft
• Halberstadt C.V, a World War I German single-engined reconnaissance biplane
• Fokker C-5, an American military version of the Fokker F.VII aircraft
• SM UC-5, a 1915 German Type UC I U-boat
• C-5 (blimp), a United States Navy airship that attempted a trans-Atlantic flight in 1919

• C5 automatic, a successor to Ford C4 transmission
• Chevrolet Corvette C5, the fifth generation of the Chevrolet Corvette sports car
• Citroën C5, a car manufactured by Citroën
• Omoda C5, a car manufactured by Chery
• Sauber C5, a sportscar by Sauber
• Audi A6 (C5), the second generation of the Audi A6 built from 1997 to 2004
• Sinclair C5, an electric vehicle designed by Clive Sinclair
• Circumferential Road 5 or C-5, an arterial road of Manila, Philippines

• Kinner C-5, an American five cylinder radial engine for small aircraft of the 1930s
• Spartan C5, a passenger and utility aircraft produced in the United States in the early 1930s

• Bavarian C V, an 1899 German express train locomotive model
• WLWR Class C5, a Waterford, Limerick and Western Railway Irish steam locomotive
• Finnish Steam Locomotive Class C5
• LNER Class C5, a class of British steam locomotives

• Crown C-5, a series of forklifts by the Crown Equipment Corporation
• Saturn C-5, an American man-rated expendable rocket

• Cervical vertebra 5, one of the cervical vertebrae of the vertebral column
• Cervical spinal nerve 5
• Complement component 5, a protein of the complement system
  • C5-convertase, an enzyme which splits C5 into C5b
  • Complement component 5a, an inflammatory peptide
• ATC code C05 Vasoprotectives, a subgroup of the Anatomical Therapeutic Chemical Classification System
• C05, Malignant neoplasm of palate ICD-10 code

• C5 (classification), a Paralympic cycling classification
• C5 Envelope size
• C5, a decision tree learning algorithm
• C5 Generic Collection Library for C Sharp and CLI, a software library by Niels Kokholm and Peter Sestoft
• C5 line socket, a polarised, three pole, mains voltage IEC appliance connector
• ChorusOS, a computer operating system
• C5, CommutAir IATA code
• C5 or Tenor C, a musical note
• c5, a square of the chessboard using algebraic chess notation
• Microsoft Dynamics C5, enterprise resource planning software
• Channel 5 (disambiguation)
• Nokia C5 (disambiguation), a series of smartphones
• Caldwell 5 (IC 342), an intermediate spiral galaxy in Camelopardalis
• Concrete5, an open source content management system
• A line of earphones from Bowers & Wilkins
• Tha Carter V, a 2018 album by Lil Wayne
• Central 5, an informal political cooperation between Austria, the Czech Republic, Hungary, Slovakia, and Slovenia
• C₅, the cycle graph with 5 vertices

• CV (disambiguation)
• 5C (disambiguation)