Protein-coding gene in the species Homo sapiens
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene .[ 5] [ 6]
The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages . This gene product catalyzes the formation of the glycosaminoglycan -protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans .[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000149541 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071649 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K (Apr 1998). "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans" . J Biol Chem . 273 (12): 6615–8. doi :10.1074/jbc.273.12.6615 PMID 9506957 . ^ a b "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)" .
External links Human B3GAT3 B3GAT3 UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : O94766 PDBe-KB .
Further reading
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Venkatesan N, Barré L, Benani A, et al. (2005). "Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair" . Proc. Natl. Acad. Sci. U.S.A . 101 (52): 18087–92. doi :10.1073/pnas.0404504102 PMC 535800 PMID 15601778 . Gulberti S, Lattard V, Fondeur M, et al. (2005). "Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans" . J. Biol. Chem . 280 (2): 1417–25. doi :10.1074/jbc.M411552200 PMID 15522873 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gulberti S, Fournel-Gigleux S, Mulliert G, et al. (2003). "The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif" . J. Biol. Chem . 278 (34): 32219–26. doi :10.1074/jbc.M207899200 PMID 12794088 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Kitagawa H, Taoka M, Tone Y, Sugahara K (2001). "Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization" . Biochem. J . 358 (Pt 3): 539–46. doi :10.1042/0264-6021:3580539 . PMC 1222090 PMID 11535117 . Pedersen LC, Tsuchida K, Kitagawa H, et al. (2000). "Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I" . J. Biol. Chem . 275 (44): 34580–5. doi :10.1074/jbc.M007399200 PMID 10946001 . Ouzzine M, Gulberti S, Netter P, et al. (2000). "Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues" . J. Biol. Chem . 275 (36): 28254–60. doi :10.1074/jbc.M002182200 PMID 10842173 . Tone Y, Kitagawa H, Imiya K, et al. (1999). "Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans" . FEBS Lett . 459 (3): 415–20. Bibcode :1999FEBSL.459..415T . doi :10.1016/S0014-5793(99)01287-9 PMID 10526176 . S2CID 7878952 . Herman T, Horvitz HR (1999). "Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway" . Proc. Natl. Acad. Sci. U.S.A . 96 (3): 974–9. Bibcode :1999PNAS...96..974H . doi :10.1073/pnas.96.3.974 PMC 15335 PMID 9927678 .
PDB gallery
1fgg : CRYSTAL STRUCTURE OF 1,3-GLUCURONYLTRANSFERASE I (GLCAT-I) COMPLEXED WITH GAL-GAL-XYL, UDP, AND MN2+
1kws : CRYSTAL STRUCTURE OF BETA1,3-GLUCURONYLTRANSFERASE I IN COMPLEX WITH THE ACTIVE UDP-GLCUA DONOR
