Asclepiodotus may refer to:

• Asclepiodotus of Heraclea (fl. 2nd century BC), commander in the Macedonian army during the Third Macedonian War
• Asclepiodotus (philosopher) (fl. 1st century BC), philosopher, writer, and pupil of Posidonius
• Asclepiodotus of Lesbos (fl. 1st century BC), conspirator against Mithridates VI of Pontus
• Cassius Asclepiodotus (fl. 1st century AD), wealthy Bithynian exiled by Nero
• Julius Asclepiodotus (fl. 3rd century AD), Roman prefect and consul who served under Aurelian, Probus and Diocletian
• Asclepiodotus (consul 423)
• Asclepiodotus of Alexandria (fl. 5th century AD), Greek Neoplatonist philosopher
• Asclepiodotus (physician) (fl. 5th century AD), Greek physician
• King Asclepiodotus, mythical king in the time of Diocletian