Ann, Anne or Annie Clark may refer to:

• Annie Clark (physician) (1844–1925), Scottish medical doctor
• Ann Nolan Clark (1896–1995), American writer
• Anne Clark (netball) (1903–1983), Australian sportswoman
• Anne Clark Martindell (1914–2008, née Clark), American politician
• Anne Rogers Clark (1929–2006), American dog breeder and show judge
• Anne Clark (poet) (born 1960), English poet, songwriter and electronic musician
• Anne Erin "Annie" Clark (born 1982), known as St. Vincent, American musician
• Annie E. Clark (born 1989), Women's rights campaigner
• Annie Clark (actress) (born 1992), Canadian actress known for Degrassi: The Next Generation

• Anne Clarke (disambiguation)
• Anna Clark (disambiguation)