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6-APBT

6-APBT
Clinical data
Other names6-(2-Aminopropyl)-1-benzothiophene; 6-APBT; 6-APBTP
Drug classSerotonin–norepinephrine–dopamine releasing agent; Serotonin 5-HT2 receptor agonist; Entactogen; Serotonergic psychedelic
Identifiers
  • 1-(1-benzothiophen-6-yl)propan-2-amine
Chemical and physical data
FormulaC11H13NS
Molar mass191.29 g·mol−1
3D model (JSmol)
  • CC(N([H])[H])CC1=CC2SC=CC=2C=C1
  • InChI=InChI=1S/C11H13NS/c1-8(12)6-9-2-3-10-4-5-13-11(10)7-9/h2-5,7-8H,6,12H2,1H3
  • Key:QBWPJANWKXULQZ-UHFFFAOYSA-N

6-(2-Aminopropyl)-1-benzothiophene (6-APBT) is a monoamine releasing agent and serotonin receptor agonist of the amphetamine and benzothiophene families.[1][2] It is related to MDA and other MDA bioisosteres like the benzofurans.[1][2]

The drug acts as a potent and well-balanced serotonin–norepinephrine–dopamine releasing agent (SNDRA) and full agonist of the serotonin 5-HT2 receptors.[2] 6-APBT does not increase locomotor activity in rodents and hence does not appear to have stimulant-like effects.[2] However, it does produce the head-twitch response, a behavioral proxy of psychedelic effects, and hence may have hallucinogenic effects.[2]

6-APBT was first described in the scientific literature by 2020.[1][2]

See also

References

  1. ^ a b c Brandt SD, Carlino L, Kavanagh PV, Westphal F, Dreiseitel W, Dowling G, et al. (August 2020). "Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants". Drug Testing and Analysis. 12 (8): 1109–1125. doi:10.1002/dta.2813. PMC 8281332. PMID 32372465.
  2. ^ a b c d e f Rudin D, McCorvy JD, Glatfelter GC, Luethi D, Szöllősi D, Ljubišić T, et al. (March 2022). "(2-Aminopropyl)benzo[β]thiophenes (APBTs) are novel monoamine transporter ligands that lack stimulant effects but display psychedelic-like activity in mice". Neuropsychopharmacology. 47 (4): 914–923. doi:10.1038/s41386-021-01221-0. PMC 8882185. PMID 34750565.
Quelle: https://en.wikipedia.org/wiki/6-APBT