The 1959 North Texas State Eagles football team represented the University of North Texas as a member of the Missouri Valley Conference (MVC) during the 1959 college football season. The Eagles, coached by Odus Mitchell, compiled a 9–2 record, and outscored their opponents 303 to 103. The Eagles were ranked for two weeks in the AP Poll. They shared the MVC title with Houston and finished the season with a 28–8 loss to New Mexico State in the 1959 Sun Bowl.

Date	Opponent	Rank	Site	Result	Attendance	Source
September 17	at Hardin–Simmons*		Public Schools Stadium Abilene, TX	W 46–24	11,000	[1]
September 26	at Texas Western*		Kidd Field El Paso, TX	W 31–7
October 3	West Texas State		Fouts Field Denton, TX	W 28–6
October 10	at Cincinnati*		Nippert Stadium Cincinnati, OH	W 21–6
October 17	Pensacola NAS*		Fouts Field Denton, TX	W 43–0
October 24	at Houston		Rice Stadium Houston, TX	W 7–6
October 31	Wichita		Fouts Field Denton, TX	W 12–0
November 7	Louisville*	No. 20	Fouts Field Denton, TX	W 39–7
November 14	at Tulsa	No. 16	Skelly Field at H. A. Chapman Stadium Tulsa, OK	L 6–17	6,872
November 21	Drake*		Fouts Field Denton, TX	W 62–2
December 31	vs. New Mexico State*		Kidd Field El Paso, TX (Sun Bowl)	L 8–28	14,000
*Non-conference game Homecoming Rankings from AP Poll released prior to the game